A Fault Detection Mechanism in Erasure-Code Byzantine Fault-Tolerance Quorum

Fault-tolerance is increasingly significant for large-scale storage systems in which Byzantine failure of storage nodes may happen. Traditional Byzantine Quorum systems that tolerate Byzantine failures by using replication have two main limitations： low space-efficiency and static quorum variables. We propose an Erasure-code Byzantine Fault-tolerance Quorum that can provide high reliability with far lower storage overhead than replication by adopting erasure code as redundancy scheme. Through read/write operations of clients and diagnose operation of supervisor, our Quorum system can detect Byzantine nodes, and dynamically adjust system size and fault threshold. Simulation results show that our method improves performance for the Quorum with relatively small quorums.     

Immune responses of a designed HIV-1 DNA vaccine on rhesus monkeys

According to the UNAIDS/WHO report (http:// www.unaids.org/Epi2005/doc/report.html), there are about 40.3 million HIV/AIDS survivors, and the new HIV infection number amounts to about 4.9 million, while the death number is some 3.1 million in the world in…     

Construction and anti-tumor effects of recombinant fowlpox virus expressing Newcastle disease virus hemagglutinin-neuramidinase gene

Hemagglutinin-neuramidinase (HN), a Newcastle disease virus-derived protein, not only mediates receptor recognition but also possesses neuraminidase (NA) activity, the ability to cleave a component of those receptors, N-acetylneuraminic acid (NAcneu, sialic acid). It is known that this protein in mammalian species, including human beings, has interesting anti-neoplastic as well as immune stimulating properties. To explore the use of the HN gene in cancer gene therapy, we constructed a recombi-nant fowlpox virus expressing the HN protein (vFV-HN) and compared the anti-tumor activity of the recombinant virus with that of wild-type fowlpox virus (FPV) in vivo and in vitro. Here we found that although B16 cells were somewhat resistant to the basal cytotoxic effect of wild-type fowlpox virus, infection with vFV-HN caused a pronounced cytotoxic effect and, the survival of tumor-bearing mice immunized with vFV-HN was significantly increased compared with the survival of mice immunized with the FPV alone. Furthermore, the immunization of mice with vFV-HN elicited a B16 tumor-specific cytotoxic T lymphocyte (CTL) response and clonal expansion of both CD4 and CD8 T cell populations in vivo. In addition, T cells from lymph nodes of mice vaccinated with vFV-HN secreted high levels of the Th1 cytokine IL-2 and IFN-γ, indicating that the regression of tumor cells is related to a Th1-type dominant immune response. These results demonstrate that vaccination with vFV-HN may be a potential strategy for cancer gene therapy.     

Rational design of glycerol dehydratase： Swapping the genes encoding the subunits of glycerol dehydratase to improve enzymatic properties

1,3-propanediol (1,3-PD) is an important material for chemical industry,and there has been always much interest in the production of 1,3-PD using all possible routes. The genes encoding glyc-erol dehydratase (GDHt) from Citrobacter freundii,Klebsiella pneumoniae and metagenome were cloned and expressed in E. coli. All glycerol dehy-dratases but the one from metagenome could be detected to show enzyme activities. In order to im-prove the enzymatic properties of GDHts,the genes encoding α and β-γ subunits were cloned,and the enzyme characteristics were evolved by rational de-sign based on their 3D structures which were con-structed by homology modeling. Six heteroenzymes were obtained by swapping the α subunit genes of these three different-source-derived GDHts. The pH,thermal stability and Vmax of some heteroenzymes were dramatically improved by 2―5 times compared with the wild one (GDHtKP). The GDHt cloned from metagenome,originally proved to be with no enzyme activity,was converted into active enzyme by swap-ping its subunits with other different GDHts. In addi-tion,the effect of subtle 3D structural changes on the properties of the enzyme was also observed.     

改善彩色等离子体显示器动态假轮廓的动态复合寻址技术

开发了一种改善彩色等离子体显示器动态假轮廓的新型动态复合寻址技术．该技术基于寻址与显示分离技术，将对产生动态假轮廓起重要作用的权值较大子场拆分为若干个权值较小的子场，并对拆分的子场使用累积发光的寻址方式，利用输入图像灰度统计与预置的灰度阈值比较，动态地确定拆分子场的使用情况，在不影响图像显示亮度的情况下有效地减小了动态假轮廓现象．同时，利用拆分多个子场、设置多阈值、增加子场数目、使用遗传算法修正编码、联合方式等改进技术，充分发挥子场数目多、子场冗余、拆分子场的特点，进一步减小了动态假轮廓．仿真结果表明，改善动态假轮廓的新型动态复合寻址技术有效地减小了动态假轮廓现象，并最大限度地提高了整幅图像的显示质量．     

网格记账系统研究与实现

该文主要介绍了基于开放网格服务体系结构(OGSA)的山东大学网格记账系统-SDUGAS,该系统主要致力于解决网格环境下异构资源使用的记账和计费问题,为用户和管理员提供良好的网格服务,在此基础上大力提高网格资源的利用率。该文将重点介绍SDUGAS的体系结构、实现的基本原理和方法、资源消费信息的采集过程、资源的价格策略以及网格银行的设计与实现等内容．并且在最后给出了一个SDUGAS记账和计费过程的简单实例。     

三脚架多齿胺Mn(II)、Ni(II)配合物仿酶性能研究

合成了三-(6-甲基-2-吡啶甲基)胺(TLA)的叠氮桥联双核锰(II)、镍(II)配合物,对两种金属配合物模拟甲基单加氧酶催化苯乙烯环氧化反应的性能进行了研究,并讨论了温度、催化剂浓度等反应条件对催化作用的影响,分析了分子结构与催化活性的关系.通过对EPR光谱和UV-v is光谱的研究,得到了高价金属氧酰(M=O)活性中间物的信息,提出了反应机理.应用比色法考察了两种配合物对羟基自由基的清除作用.     

如何做好医疗保险统计工作

根据自身工作实际,分析了长治市医疗保险统计工作的现状,对进一步加强工作提出了几点建议。     

Mg+x% Mm(NiCoMnAl)5复合储氢材料吸放氢性能研究

采用高能球磨法制备了Mg x%Mm(NiCoMnAl)_5(x=10、20、30和40)纳米晶和非晶混合结构的复合储氢材料,并对其结构和吸放氢性能进行了研究．XRD结果表明,Mg与Mm(NiCoMnAl)_5球磨200h后有Mg_2Ni和La_2Mg_(17)相生成．吸氢动力学研究发现,在423K和3．4 MPa下,随着x增大,吸氢速率和最大吸氢量都出现了先增大后减小的趋势．当x=20时,复合材料的吸氢性能达到最佳,其最大吸氢速率达到0．45%/s,50s内即可吸氢3．6%．热重分析结果表明,Mg的氢化物相放氢温度降低到259℃(x=40)．     

高温超导滤波器研制

设计并制作了中心频率为2 007.5MH z,带宽为15MH z的6阶T l2B a2C aCu2O8高温超导微带滤波器.采用在谐振器之间插入微带条来微调耦合间距的办法,提高了设计的精确度.实测结果表明滤波器的最小插入损耗为0.25 dB,带外抑制约60 dB,带内波纹为0.16 dB,中心频率、带宽以及边带陡峭度等都与仿真结果吻合较好,验证了设计与制作的一致性.